MSH2mutations are associated with the development of colorectal cancer and are a common cause of Lynch syndrome. Jeans et al. describe the case of a 37-year-old woman with a germline MSH2mutation who developed rectal adenocarcinoma and 7 years later presented with a primitive neuroectodermal tumor. The authors suggest that diagnosis of Lynch syndrome should be considered in cases where individuals with previous malignancies associated with this syndrome present with cerebral tumors.
- Alexander F. Jeans
- Ian Frayling
- Olaf Ansorge
