PrPSc, the infective agent for transmissible spongiform encephalopathies, is the misfolded form of the prion protein that can template the conversion of the native fold of the protein (PrPC). The high-resolution structure of PrPSc remains elusive. This review presents recent progress in the area and existing structural models, in addition to discussing the challenges ahead.
- Rodrigo Diaz-Espinoza
- Claudio Soto