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Showing 1–4 of 4 results
Advanced filters: Author: "Clifford J. Woolf" Clear advanced filters

  • Optogenetic methods to control nociceptors open up a wealth of potential applications in pain research and therapy.

    • Liam E Browne
    • Clifford J Woolf
    News & Views
    Nature Biotechnology
    Volume: 32, P: 240-241

  • Existing pain therapies are often inadequate or associated with side effects. Here, Woolf and colleagues discuss new and existing strategies for the development of improved pain therapeutics, highlighting key challenges and considerations in the clinical development of novel analgesics.

    • Ajay S. Yekkirala
    • David P. Roberson
    • Clifford J. Woolf
    Reviews
    Nature Reviews Drug Discovery
    Volume: 16, P: 545-564

  • Transient receptor potential (TRP) channels are the most prominent family of nociceptive ion-channel transducer proteins. This Review highlights evidence supporting particular TRP channels as targets for analgesics, indicates the likely efficacy profiles of TRP-channel-acting compounds and looks at recent clinical trials with TRP-channel-acting drugs.

    • Ardem Patapoutian
    • Simon Tate
    • Clifford J. Woolf
    Reviews
    Nature Reviews Drug Discovery
    Volume: 8, P: 55-68