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Showing 1–2 of 2 results
Advanced filters: Author: "Clifford Jack" Clear advanced filters

  • The hippocampus is a dynamic structure that can change in size throughout life. Hippocampal atrophy, which is associated with cognitive decline and late-life dementia, can be exacerbated by a number of medical conditions. In this Review, Fotuhi and colleagues examine the modifiable factors that can affect hippocampal size, and discuss lifestyle and therapeutic interventions that might prevent or even reverse hippocampal atrophy.

    • Majid Fotuhi
    • David Do
    • Clifford Jack
    Reviews
    Nature Reviews Neurology
    Volume: 8, P: 189-202

  • MRI-based structural imaging has become an integral component of the clinical assessment of patients with suspected Alzheimer disease (AD), and atrophy of medial temporal structures is now considered to be a valid diagnostic marker at the mild cognitive impairment stage. In this article, Frisoni et al. consider the roles of structural MRI markers in the diagnosis of AD and non-AD dementias, and in the tracking of disease progression during clinical trials.

    • Giovanni B. Frisoni
    • Nick C. Fox
    • Paul M. Thompson
    Reviews
    Nature Reviews Neurology
    Volume: 6, P: 67-77