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Showing 1–6 of 6 results
Advanced filters: Author: "Connie Cepko" Clear advanced filters

  • Retinitis pigmentosa causes the death of cone cells, leading to blindness. A factor secreted from rod cells, RdCVF, promotes cone survival in a mouse model of the disease. It now emerges that RdCVF works by increasing glucose uptake in cones.

    • Connie Cepko
    • Claudio Punzo
    News & Views
    Nature
    Volume: 522, P: 428-429

  • In this article, the authors review the current understanding of the molecular mechanisms underlying cell type identity and discuss how new phenotypic features of cell types evolve. They explain how evolutionary lineage differs from developmental lineage and highlight how an evolutionary view of cell type identity can facilitate research in comparative cell biology.

    • Detlev Arendt
    • Jacob M. Musser
    • Günter P. Wagner
    Reviews
    Nature Reviews Genetics
    Volume: 17, P: 744-757

  • Retinal progenitor cells (RPCs) produce all of the retina's cells through an evolutionarily conserved series of divisions and cell fate decisions. In this article, Cepko describes recent studies that have shed light on the intrinsic and extrinsic mechanisms that drive this process and argues that individual terminally dividing RPCs are molecularly specified to produce particular progeny.

    • Connie Cepko
    Reviews
    Nature Reviews Neuroscience
    Volume: 15, P: 615-627