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Showing 1–2 of 2 results
Advanced filters: Author: "Craig H Bassing" Clear advanced filters

  • Immature B lymphocytes and T lymphocytes assemble antigen receptor–encoding genes in lineage- and developmental stage–specific fashion. New findings show that pre-B cells use specialized locus-specific epigenetic mechanisms to promote recombination of the locus encoding the immunoglobulin κ-chain (Igk) and κ-chain+ B cell development.

    • Megan R Fisher
    • Craig H Bassing
    News & Views
    Nature Immunology
    Volume: 16, P: 1007-1009

  • B cell tolerance is achieved in part through secondary rearrangements that replace ('edit') exons encoding autoreactive antigen-receptor chains. New findings suggest that Foxo transcription factors are critical regulators of receptor editing by activating the transcription of recombination-activating genes.

    • Marta A W Rowh
    • Craig H Bassing
    News & Views
    Nature Immunology
    Volume: 9, P: 586-588