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Showing 1–4 of 4 results
Advanced filters: Author: "Cyrus M Ghajar" Clear advanced filters

  • In a recent study in mice, researchers combined tumor barcoding with unbiased genomic analysis and identified Cd109 as a hub gene involved in metastatic progression. They show that pharmacological inhibition of its downstream effectors JAK1 and STAT3 curtails metastatic growth.

    • Laura Pisarsky
    • Jinxiang Dai
    • Cyrus M Ghajar
    News & Views
    Nature Medicine
    Volume: 23, P: 275-276

  • Two studies in mice identify mechanisms by which tumour cells disseminate in very early breast cancer. Both show that these cells colonize distant tissues more efficiently than their later counterparts. See Article p.552 & Letter p.588

    • Cyrus M. Ghajar
    • Mina J. Bissell
    News & Views
    Nature
    Volume: 540, P: 528-529

  • This Opinion article advocates therapeutically targeting the niches that harbour dormant disseminated tumour cells in order to make them susceptible to cytotoxic agents. Similar strategies have sensitized leukaemic cells and latent HIV to therapy, and such an approach might delay or even prevent metastasis.

    • Cyrus M. Ghajar
    Reviews
    Nature Reviews Cancer
    Volume: 15, P: 238-247

  • This Review summarizes the natural progression of pre-metastatic niche formation and evolution, highlighting recent advances and future hurdles.

    • Héctor Peinado
    • Haiying Zhang
    • David Lyden
    Reviews
    Nature Reviews Cancer
    Volume: 17, P: 302-317