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  • Down syndrome (DS) is caused by trisomy 21 (T21), but the underlying etiology of the related immune and neurological dysfunction is unclear. Here, the authors show that T21 activates the kynurenine pathway via increased interferon receptor copy number, which could contribute to DS pathophysiology.

    • Rani K. Powers
    • Rachel Culp-Hill
    • Joaquin M. Espinosa
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11