The authors review the roles of T3 in skeletal muscle development, homeostasis and pathology, with a focus on the emerging local deiodinase-mediated control of T3signalling. Moreover, this Review addresses how manipulation of deiodinase activity in skeletal muscle might be therapeutically harnessed to improve satellite-cell-mediated muscle repair in patients with skeletal muscle disorders, muscle atrophy or injury.
- Domenico Salvatore
- Warner S. Simonides
- P. Reed Larsen
