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Showing 1–16 of 16 results
Advanced filters: Author: "D. Young" Clear advanced filters
  • An unexpected function has been assigned to part of the molecular machinery that synthesizes the bacterial cell wall — a dramatic shift in our understanding that may have major implications for antibiotic development. See Article p.634

    • Kevin D. Young
    News & Views
    Nature
    Volume: 537, P: 622-624
  • The proton can contain pairs of elementary particles known as strange quarks. The contribution of these particles to the proton's electric-charge distribution and magnetic moment has been determined.

    • Ross D. Young
    News & Views
    Nature
    Volume: 544, P: 419-420
  • New approaches are required for the prevention and treatment of obesity and its associated pathologies. Here, Martel and colleagues review the potential anti-obesogenic and antidiabetic effects of plants, mushrooms and their derivatives, some of which have longstanding uses in traditional Chinese medicine.

    • Jan Martel
    • David M. Ojcius
    • John D. Young
    Reviews
    Nature Reviews Endocrinology
    Volume: 13, P: 149-160
  • With annual deaths fromMycobacterium tuberculosisestimated at around three million, this single pathogen claims more human lives than any other. What we now learn from the sequence of its genome should help in devising new strategies to fight it.

    • Douglas B. Young
    News & Views
    Nature
    Volume: 393, P: 515-516
  • Restoration of genes lost during the original attenuation of the commonly used BCG tuberculosis vaccine enhances the ability of a recombinant strain to protect against Mycobacterium tuberculosis.

    • Douglas B. Young
    News & Views
    Nature Medicine
    Volume: 9, P: 503-504
  • The European Patent Convention (EPC) states that a patent or patent application cannot be amended in such a way that it contains subject matter that extends beyond the content of the application as filed. It seems that the European Patent Office (EPO) is interpreting this provision with ever-increasing severity. This article considers the effects of this and related provisions to inventors in obtaining patent protection for their inventions in Europe and also consider the consequences of 'flouting the rules'

    • Candi Soames
    News
    Nature Reviews Drug Discovery
    Volume: 4, P: 531
  • Although methods of medical treatment per se are not patentable in Europe, the use of agents or products in the preparation of medicaments for such treatments are. The drawbacks of such limited protection is clear. The European Patent Office is becoming ever more stringent in their requirements for the presence of experimental data in support of the medical use to be present in the application on filing. Whether Europe will ever harmonize with the US in allowing the protection of medical methods is not clear. Until then the burden on inventors to obtain patent protection for medical-use-type inventions is significant and the return is far from adequate.

    • Candi Soames
    News
    Nature Reviews Drug Discovery
    Volume: 4, P: 951
  • Patent systems were designed to encourage and reward innovation. A system that prevents research into the subject matter covered by a patent would be inconsistent with such goals, and so the patent systems of most countries contain a provision that exempts from infringement experiments performed relating to the subject matter of a patent. In this article, the extent of the exclusion for experimental acts in Europe, particularly the UK, is discussed. I consider what constitutes an experimental act and to what extent the experimental use provision can effect scientific development.

    • Candi Soames
    News
    Nature Reviews Drug Discovery
    Volume: 4, P: 271
  • The complete genome sequence of Mycobacterium tuberculosis, along with novel genetic tools, provides the foundation for a new era of post-genomic research. The challenge is now to translate these opportunities into an improved understanding of the complex biology of tuberculosis infection.

    • Douglas B. Young
    Comments & Opinion
    Nature Medicine
    Volume: 7, P: 11-13
  • In the first of a series of articles that focus on systems biology in microorganisms, Douglas Young and colleagues describe how systems biology provides a new and integrative tool that can be used to probe host–pathogen interactions during persistent infection, usingMycobacterium tuberculosisas an example.

    • Douglas Young
    • Jaroslav Stark
    • Denise Kirschner
    Reviews
    Nature Reviews Microbiology
    Volume: 6, P: 520-528
  • Nearly one-third of the world's population is infected withMycobacterium tuberculosis. In this Review, Young and colleagues describe the different forms the infection can take, how imaging techniques can help us understand the range of infections and how these findings can be used for drug discovery approaches.

    • Clifton E. Barry 3rd
    • Helena I. Boshoff
    • Douglas Young
    Reviews
    Nature Reviews Microbiology
    Volume: 7, P: 845-855