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Showing 1–2 of 2 results
Advanced filters: Author: "Da-Zhi Wang" Clear advanced filters

  • Intercalated discs ensure mechanical and electrochemical coupling during contraction of the heart. Here, the authors show that loss of Xinβ results in cardiomyocyte proliferation defects and cardiomyopathy by influencing the Hippo-YAP signalling pathway, thus affecting cardiac development and function.

    • Haipeng Guo
    • Yao Wei Lu
    • Da-Zhi Wang
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • The miR-17-92 cluster has been shown to regulate cardiomyocyte proliferation in vitro and in genetic mutation and overexpression models. Here the authors show that the cluster member miR-19a/19b regulates cardiomyocyte proliferation in vivo, and that delivery of miR-19a/19b to the heart leads to both short-term and long-term protective responses to myocardial infarction.

    • Feng Gao
    • Masaharu Kataoka
    • Da-Zhi Wang
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15