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Showing 1–9 of 9 results
Advanced filters: Author: "Dale I. Godfrey" Clear advanced filters

  • Natural killer T cells (NKT cells) recognize lipid-based antigens presented by CD1d. The mammalian glycolipid β-glucosylceramide, a ubiquitous self antigen for NKT cells, is upregulated by microbial danger signals, which leads to activation of NKT cells in the absence of foreign glycolipid antigen.

    • Dale I Godfrey
    • Daniel G Pellicci
    • Jamie Rossjohn
    News & Views
    Nature Immunology
    Volume: 12, P: 1135-1137

  • Aspergillus fumigatus is a fungus that is associated with a severe form of asthma, although the precise immunological basis for this disease is unclear. A new study in mice shows that natural killer T (NKT) cells are crucial for progression of A. fumigatus–induced asthma and also identifies a glycolipid antigen from this fungus that seems to drive this NKT cell–mediated inflammatory response (pages 1297–1304).

    • Dale I Godfrey
    • Daniel G Pellicci
    • Jamie Rossjohn
    News & Views
    Nature Medicine
    Volume: 19, P: 1210-1211

  • Although the development of natural killer T cells is a T cell antigen receptor–dependent process, the signaling pathways involved are poorly defined. New data demonstrate that the calcineurin–transcription factor NFAT pathway exerts a critical influence on this process by controlling the transcription factor Egr2.

    • Dale I Godfrey
    • Sanda Stankovic
    • Alan G Baxter
    News & Views
    Nature Immunology
    Volume: 10, P: 231-233

  • Here, the authors discuss how the T cell receptors expressed by natural killer T cells are able to recognize and respond to an array of self and foreign lipid antigens that are presented on CD1d molecules. They explain how a better understanding of these processes could be exploited for therapeutic purposes.

    • Jamie Rossjohn
    • Daniel G. Pellicci
    • Dale I. Godfrey
    Reviews
    Nature Reviews Immunology
    Volume: 12, P: 845-857

  • Mucosal-associated invariant T cells are evolutionarily conserved T lymphocytes with undefined antigen specificity. These cells are now shown to have a unique role in host defense by targeting highly conserved microbial antigens.

    • Dale I Godfrey
    • Jamie Rossjohn
    • James McCluskey
    News & Views
    Nature Immunology
    Volume: 11, P: 693-695

  • Whereas the adaptive immune response is essential for control and clearance of hepatitis B virus infection, the importance of the early innate immune response is controversial and the players involved are poorly defined. A new study shows that activation of natural killer T cells by infected hepatocytes is crucial for the early control of this disease (pages 1060–1068).

    • Dale I Godfrey
    • Adam P Uldrich
    • Alan G Baxter
    News & Views
    Nature Medicine
    Volume: 18, P: 1014-1016

  • Several diseases are associated with reduced numbers of natural killer T (NKT) cells. The authors of this Review ask what drives NKT-cell development in the thymus and what factors ensure NKT-cell survival, maturation and function in the periphery?

    • Dale I. Godfrey
    • Stuart P. Berzins
    Reviews
    Nature Reviews Immunology
    Volume: 7, P: 505-518

    • Dale I. Godfrey
    • H. Robson MacDonald
    • Luc Van Kaer
    Reviews
    Nature Reviews Immunology
    Volume: 4, P: 231-237

  • This Review focuses on the lesser studied antigen-presenting molecules group 1 CD1 proteins and MHC class I-related protein (MR1). The authors explain how their mode of presentation of lipids and small molecules to T cells differs from that of peptide–MHC presentation, and how new technologies are revealing unique T cell subsets that are specific for CD1 and MR1 proteins.

    • Ildiko Van Rhijn
    • Dale I. Godfrey
    • D. Branch Moody
    Reviews
    Nature Reviews Immunology
    Volume: 15, P: 643-654