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Showing 1–6 of 6 results
Advanced filters: Author: "Dana J. Philpott" Clear advanced filters

  • Given the rise of antibiotic resistance and the decreasing rate of discovery of new antimicrobials, exploring new paradigms for antimicrobial therapy is essential. Here, Hancock, Nijnik and Philpott describe the promise of one such alternative approach: host-directed immunomodulatory therapies for enhancing protective antimicrobial immunity.

    • Robert E. W. Hancock
    • Anastasia Nijnik
    • Dana J. Philpott
    Reviews
    Nature Reviews Microbiology
    Volume: 10, P: 243-254

  • Microbes in the gut can influence distant events, affecting the function of neutrophils in the circulation of mice (pages 228–231). The findings should lead to new studies examining how intestinal microbes affect immunity.

    • Dana J Philpott
    • Stephen E Girardin
    News & Views
    Nature Medicine
    Volume: 16, P: 160-161

  • The 3020insC mutation in Nod2 is associated with Crohn's disease, but how it influences disease pathogenesis is unknown. A new study shows that the 3020insC mutant protein fails to activate a key transcription factor that drives interleukin 10 expression, resulting in reduced production of this anti-inflammatory cytokine.

    • Dana J Philpott
    • Stephen E Girardin
    News & Views
    Nature Immunology
    Volume: 10, P: 455-457

  • Paneth cell dysfunction has been linked to Crohn's disease. Nod2 and LRRK2, two genetic susceptibility factors for this disease, are now shown to have a role in regulating the sorting of lysozyme in Paneth cells and its secretion into the crypt space and, ultimately, in maintenance of the intestinal barrier.

    • Juliana D B Rocha
    • Michael G Schlossmacher
    • Dana J Philpott
    News & Views
    Nature Immunology
    Volume: 16, P: 898-900

  • Nucleotide oligomerization domain-containing protein 1 (NOD1) and NOD2 are pattern-recognition receptors that detect bacterial peptidoglycan. Signalling through NODs initiates a variety of effector immune responses that seem to be crucial for maintaining immune homeostasis with the host microbiota. Indeed, mutations in NOD1 and NOD2 are associated with both intestinal and extra-intestinal disease. This Review summarizes our current understanding of the NODs.

    • Dana J. Philpott
    • Matthew T. Sorbara
    • Stephen E. Girardin
    Reviews
    Nature Reviews Immunology
    Volume: 14, P: 9-23

  • Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are a family of intracellular sensors that have key roles in innate immunity and inflammation. This Review discusses the effect that research on NLRs will have on vaccination, treatment of chronic inflammatory disorders and acute bacterial infections.

    • Kaoru Geddes
    • João G. Magalhães
    • Stephen E. Girardin
    Reviews
    Nature Reviews Drug Discovery
    Volume: 8, P: 465-479