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Showing 1–3 of 3 results
Advanced filters: Author: "Daniel C. Douek" Clear advanced filters

  • The lack of natural immunity against HIV has been a major hindrance to the search for immune correlates of protection. Here, the authors propose a new approach for clinical trials of HIV vaccine efficacy that should help to increase our chances of identifying immune correlates of protection.

    • Richard A. Koup
    • Barney S. Graham
    • Daniel C. Douek
    Reviews
    Nature Reviews Immunology
    Volume: 11, P: 65-70

  • Given that T-cell receptor (TCR) repertoires are randomly generated, how come T cells bearing identical TCRs often dominate the response to an antigen in many individuals? Here, the authors provide a molecular explanation to the conundrum of public T-cell responses.

    • Vanessa Venturi
    • David A. Price
    • Miles P. Davenport
    Reviews
    Nature Reviews Immunology
    Volume: 8, P: 231-238

  • Even when receiving antiretroviral therapy, HIV-infected individuals have an increased risk of mortality owing to systemic immune activation. Sandler and Douek review evidence showing that the translocation of microbial products from the intestine into the circulation may contribute to this risk and discuss potential therapeutic strategies.

    • Netanya G. Sandler
    • Daniel C. Douek
    Reviews
    Nature Reviews Microbiology
    Volume: 10, P: 655-666