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Showing 1–2 of 2 results
Advanced filters: Author: "Daniel D. Von Hoff" Clear advanced filters

  • Perineural invasion (PNI) is a prominent characteristic of pancreatic cancer that is involved in the generation of pain, and correlates with poor prognosis in most studies. This Review discusses the signalling molecules and pathways that are involved in PNI and whether knowledge of these could be used to alleviate pain and to reduce the incidence of PNI.

    • Aditi A. Bapat
    • Galen Hostetter
    • Haiyong Han
    Reviews
    Nature Reviews Cancer
    Volume: 11, P: 695-707

  • Following the development of the first mTOR inhibitor that successfully improves therapeutic survival in cancer, Raymond and colleagues look at how novel biomarker identification and the use of multitargeted and multimodality therapies could advance the next generation of these drugs.

    • Sandrine Faivre
    • Guido Kroemer
    • Eric Raymond
    Reviews
    Nature Reviews Drug Discovery
    Volume: 5, P: 671-688