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Showing 1–5 of 5 results
Advanced filters: Author: "Daniel J Cua" Clear advanced filters

  • T cells are intrinsically more malleable than previously thought. Two studies now show that existing T helper type 2 cells can be converted into alternative CD4+ T helper cells that coexpress interleukins 9 and 10.

    • Cristina M Tato
    • Daniel J Cua
    News & Views
    Nature Immunology
    Volume: 9, P: 1323-1325

  • A previously unknown function for TH17 cell–derived IL-26 as a direct antimicrobial agent and activator of DNA-sensing innate immunity is now reported.

    • Jacob S Lee
    • Daniel J Cua
    News & Views
    Nature Immunology
    Volume: 16, P: 897-898

  • T helper 17 (TH17) cells promote protective immune responses against infection, particularly at barrier sites, but they can also have pathogenic roles in inflammatory diseases. In this Review, the authors describe the factors that control the development and maintenance of TH17 cells, and discuss their diverse functions in both health and disease.

    • Sarah L. Gaffen
    • Renu Jain
    • Daniel J. Cua
    Reviews
    Nature Reviews Immunology
    Volume: 14, P: 585-600

  • The discovery of IL-17-producing T cells has revolutionized our understanding of autoimmune diseases. However, much of the IL-17 released during an immune response is produced before T cells can be activated. Here, Daniel Cua and Cristina Tato describe the cellular sources, transcriptional regulation and physiological relevance of this early IL-17 production.

    • Daniel J. Cua
    • Cristina M. Tato
    Reviews
    Nature Reviews Immunology
    Volume: 10, P: 479-489