All malignant cancers, whether inherited or sporadic, are fundamentally governed by Darwinian dynamics and consist of dynamically evolving clades of cells living in distinct microhabitats that almost certainly ensure the emergence of therapy-resistant populations. However, the principles of Darwinian dynamics also embody fundamental principles that can be used for the successful management of cancer.
- Robert J. Gillies
- Daniel Verduzco
- Robert A. Gatenby
