Gliomas in children differ from their adult counterparts by histological grade, site of presentation and rate of malignant transformation. Molecular profiling experiments on adult high-grade glioma have revealed key biological differences between the adult and paediatric disease. The authors summarize the current and historical data, compare and contrast the findings in these tumours across age groups, and discuss the implications for paediatric patients whose treatment options are modelled on clinical data from adult patients.
- Chris Jones
- Lara Perryman
- Darren Hargrave
