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Showing 1–3 of 3 results
Advanced filters: Author: "David A. Brown" Clear advanced filters
  • The pathophysiology of heart failure is complex, but mitochondrial dysfunction is an emerging therapeutic target to improve cardiac function. In this Consensus Statement, insights into the mechanisms of mitochondrial dysfunction in heart failure are presented, along with an overview of emerging treatments with the potential to improve the function of the failing heart by targeting mitochondria.

    • David A. Brown
    • Justin B. Perry
    • Mihai Gheorghiade
    ReviewsOpen Access
    Nature Reviews Cardiology
    Volume: 14, P: 238-250
  • Strategies to reduce myocardial infarct size beyond early reperfusion have thus far yielded disappointing results in clinical trials. In this Review, Kloner and co-workers discuss several new approaches to preserve the reperfused myocardium, including those that target mitochondrial bioenergetics and autophagy.

    • Robert A. Kloner
    • David A. Brown
    • Jianru Shi
    Reviews
    Nature Reviews Cardiology
    Volume: 14, P: 679-693