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Showing 1–2 of 2 results
Advanced filters: Author: "David A. Tuveson" Clear advanced filters

  • Comparative genomic analyses of primary tumors and metastases within individuals with pancreatic cancer have exposed the complex clonal dynamics that underlie the dissemination of cancer cells to distant sites. Recent studies implicate non-genetic mechanisms in this process, particularly fluctuations in chromatin states and metabolism, which can endow rare cells within a primary tumor with metastatic potential.

    • Christopher R Vakoc
    • David A Tuveson
    News & Views
    Nature Genetics
    Volume: 49, P: 323-324

  • When some cancer cells delete a tumour-suppressor gene, they also delete nearby genes. It emerges that one of these latter genes has a key metabolic role, revealing a therapeutic opportunity that might be relevant for many tumours. See Letter p.119

    • Giulia Biffi
    • David A. Tuveson
    News & Views
    Nature
    Volume: 542, P: 34-35