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Showing 1–9 of 9 results
Advanced filters: Author: "David B. Goldstein" Clear advanced filters

  • There could be unexpected consequences if greater understanding of disease genetics gives parents more choice in what they pass to their children, says David B. Goldstein.

    • David B. Goldstein
    Comments & Opinion
    Nature
    Volume: 476, P: 27-28

  • The identification of a set of genetic variations that are strongly associated with the risk of developing schizophrenia provides insights into the neurobiology of this destructive disease. See Article p.177

    • Ryan S. Dhindsa
    • David B. Goldstein
    News & Views
    Nature
    Volume: 530, P: 162-163

  • Humans vary in their susceptibility to HIV infection, and identifying the host genetic factors that cause this variation is a priority for vaccine development. Progress in high-throughput genotyping and in knowledge about human genetic variation allows systematic searching for genetic variants that influence the human response to HIV-1.

    • Amalio Telenti
    • David B. Goldstein
    Reviews
    Nature Reviews Microbiology
    Volume: 4, P: 865-873

  • A challenge in biology is to understand complex traits, which are influenced by many genetic variants. Studies in yeast provide the prospect of analysing such genetic variation in detail in other organisms, including humans.

    • David B. Goldstein
    • Mohamed A. F. Noor
    News & Views
    Nature
    Volume: 464, P: 985-986

  • A combination of ecological, population genetic and molecular studies has stimulated progress in understanding the forces that shape natural phenotypic variation. Technical advances that allow fitness differences to be linked to individual polymorphisms now promise rapid progress in this field.

    • Thomas Mitchell-Olds
    • John H. Willis
    • David B. Goldstein
    Reviews
    Nature Reviews Genetics
    Volume: 8, P: 845-856

  • Next-generation sequencing is now poised for the discovery of genetic variants involved in common and rare diseases. Here, the authors present considerations for the workflow of these studies in order to identify true associations of disease and mutation.

    • David B. Goldstein
    • Andrew Allen
    • Shamil Sunyaev
    Reviews
    Nature Reviews Genetics
    Volume: 14, P: 460-470

    • David B. Goldstein
    • Sarah K. Tate
    • Sanjay M. Sisodiya
    Reviews
    Nature Reviews Genetics
    Volume: 4, P: 937-947

  • The contribution of genomics to drug discovery and development so far has not yet lived up to the initial high expectations. Goldstein and colleagues discuss the reasons for the limited progress and review how recent advances — particularly in oncology and rare genetic diseases — may enable precision medicine strategies to harness the therapeutic potential of genomic knowledge.

    • Sarah A. Dugger
    • Adam Platt
    • David B. Goldstein
    Reviews
    Nature Reviews Drug Discovery
    Volume: 17, P: 183-196

  • Genome-wide association studies have explained only a small fraction of the genetic basis of complex diseases. This Review argues that rare variants could have a substantial effect on genetic predisposition to common disease, and the authors outline discovery strategies based on whole-genome sequencing for identifying these genetic risk factors.

    • Elizabeth T. Cirulli
    • David B. Goldstein
    Reviews
    Nature Reviews Genetics
    Volume: 11, P: 415-425