Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–7 of 7 results
Advanced filters: Author: "David Bentley" Clear advanced filters

  • The fate of RNAs in the nucleus is determined by the polymerase that made them. So how can we explain this link between the machines that make and process mRNAs?

    • David Bentley
    News & Views
    Nature
    Volume: 395, P: 21

  • Yra1 is an export factor known to link 3′ end formation of mRNAs to export through interaction with Pcf11, a subunit of the cleavage-polyadenylation factor CF1A. Yra1 is now found to regulate assembly of CF1A and affect poly(A) site choice.

    • Sara A Johnson
    • Hyunmin Kim
    • David L Bentley
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 1164-1171

  • Co-transcriptional splicing of pre-mRNAs has been proposed to involve exon tethering to the elongating RNA polymerase II. By inserting a fast-cleaving ribozyme in the nascent transcript, the linear integrity of the transcript is found to be key to splicing, arguing against tethering and for a pathway that clears such disrupted transcripts.

    • Nova Fong
    • Marie Öhman
    • David L Bentley
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 916-922

  • The cellular transcription, mRNA processing and export machineries seem to have co-evolved to allow spatiotemporal coupling of these processes. Here, the author reviews recent insights into the relative amount of co-transcriptional and post-transcriptional processing, the relationship between mRNA elongation and processing, and the regulating role of the carboxy-terminal domain of RNA polymerase II.

    • David L. Bentley
    Reviews
    Nature Reviews Genetics
    Volume: 15, P: 163-175

  • The C-terminal domain (CTD) of RNA polymerase II (Pol II) contains a number of repeats, phosphorylation of which influences RNA processing factor recruitment. Genome-wide CTD phosphorylation is now assessed and found not to be scaled to gene length. The kinases mediating these modifications are found not to alter Pol II distribution across a given gene uniformly, arguing that CTD phosphorylation is gene specific.

    • Hyunmin Kim
    • Benjamin Erickson
    • David L Bentley
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 1279-1286