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Showing 1–4 of 4 results
Advanced filters: Author: "David Borsook" Clear advanced filters

  • Complex regional pain syndrome is a chronic condition arising mainly after tissue injury and involves both inflammatory and neurogenic factors. Use of angiotensin-converting-enzyme inhibitors has been associated with an increased risk of developing the chronic pain condition, which suggests possible roles for substance P and bradykinin in the underlying pathogenic process.

    • David Borsook
    • Simona Sava
    News & Views
    Nature Reviews Neurology
    Volume: 5, P: 306-308

  • The causes of migraine remain unknown despite the high prevalence and societal burden of this disorder. Here, the authors highlight how advances in imaging and genetic studies of migraine provide insights into the underlying mechanisms of this disorder; furthermore, they discuss the potential for genetic and imaging biomarkers to improve our ability to prevent and treat migraine attacks.

    • Dale R. Nyholt
    • David Borsook
    • Lyn R. Griffiths
    Reviews
    Nature Reviews Neurology
    Volume: 13, P: 725-741

  • fMRI is a relatively new technology that is now being evaluated for use in drug development. This has generated significant interest from biotech and pharmaceutical companies wishing to decrease the risk of drug development. Borsooket al. examine the potential use of fMRI as a tool to integrate drug development and optimize clinical development and later stage clinical trials.

    • David Borsook
    • Lino Becerra
    • Richard Hargreaves
    Reviews
    Nature Reviews Drug Discovery
    Volume: 5, P: 411-425