The chemokine receptor CCR5 is thought to have a role in several CNS inflammatory diseases and infections. The role of CCR5 in HIV has already led to the development of effective and well-tolerated CCR5 antagonists, which could offer a readily available option for the treatment of CNS diseases. In this Review, Martin-Blondel et al. consider the evidence for a role of CCR5 in several CNS diseases and the rationale for use of CCR5 anatagonists in these conditions.
- Guillaume Martin-Blondel
- David Brassat
- Roland S. Liblau
