Regulatory T (Treg) cells have crucial roles in peripheral tolerance and limiting inflammation, and IL-2 is an important cytokine for Treg cell differentiation, activity and homeostasis. In this Review, Kolios, Tsokos and Klatzmann provide an overview of Treg cell and IL-2 involvement in rheumatic diseases and how modulating IL-2 signalling and Treg cell biology might provide novel treatment avenues.
- Antonios G. A. Kolios
- George C. Tsokos
- David Klatzmann