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Showing 1–4 of 4 results
Advanced filters: Author: "David M Holtzman" Clear advanced filters

  • The past few years have seen the identification of a growing number of risk factors for Alzheimer disease (AD). In this Perspectives article, the authors discuss the evidence for a bidirectional relationship between disrupted sleep patterns and amyloid-β accumulation, and the potential implications for disease progression in AD.

    • Yo-El S. Ju
    • Brendan P. Lucey
    • David M. Holtzman
    Reviews
    Nature Reviews Neurology
    Volume: 10, P: 115-119

  • Some samples of human growth hormone used as therapy until the mid-1980s contain amyloid-β peptide and cause genetically modified mice to develop amyloid-β deposits in the brain.

    • Tien-Phat V. Huynh
    • David M. Holtzman
    News & Views
    Nature
    Volume: 564, P: 354-355

  • An agent that clears disease-associated amyloid aggregates from the brains of patients with Alzheimer's disease does not alleviate disease progression. Yet this disappointing news should not rule out such potential therapies.

    • David M. Holtzman
    News & Views
    Nature
    Volume: 454, P: 419-420

  • In a bidirectional relationship, the sleep/wake cycle regulates amyloid-β (Aβ) levels and Aβ accumulation then disrupts sleep. A quantitative three-way model now suggests that Aβ impairs memory via its effect on sleep.

    • Brendan P Lucey
    • David M Holtzman
    News & Views
    Nature Neuroscience
    Volume: 18, P: 933-934