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Showing 1–2 of 2 results
Advanced filters: Author: "David M Thomas" Clear advanced filters

  • A wealth of recent studies has characterized roles for the Hippo pathway in diverse cancer-relevant processes. This Review discusses our latest understanding of Hippo pathway signalling in cancer, including mechanisms of pathway disruption in cancer, and the opportunities and challenges for therapeutic intervention.

    • Kieran F. Harvey
    • Xiaomeng Zhang
    • David M. Thomas
    Reviews
    Nature Reviews Cancer
    Volume: 13, P: 246-257

  • Survival for patients with metastatic or relapsed osteosarcoma has remained virtually unchanged during the past 30 years, and new therapeutic options are needed. This Review discusses normal bone biology relevant to osteosarcoma, including the immunobiology of bone, model systems for studying osteosarcoma, genetic and genomic studies on germline predisposition and tumour landscapes, and recent clinical trials.

    • Maya Kansara
    • Michele W. Teng
    • David M. Thomas
    Reviews
    Nature Reviews Cancer
    Volume: 14, P: 722-735