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Advanced filters: Author: "David Nemazee" Clear advanced filters

  • Receptor editing and apoptosis have crucial roles in promoting the central tolerance of B cells to self-antigens. Defects of these processes can result in autoimmunity or immunodeficiency disease in humans and mice.

    • David Nemazee
    Reviews
    Nature Reviews Immunology
    Volume: 17, P: 281-294

  • This Review article discusses the importance of secondary gene rearrangements in the alteration of antigen-receptor specificity by B cells and T cells, and describes how this process is facilitated by the different genomic organization of the loci that encode the two antigen-receptor chains.

    • David Nemazee
    Reviews
    Nature Reviews Immunology
    Volume: 6, P: 728-740