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Showing 1–2 of 2 results
Advanced filters: Author: "David R. Liu" Clear advanced filters

  • Directed evolution uses laboratory-based evolution to enhance the properties of biomolecules, primarily to generate proteins with optimized or novel activities. This Review discusses the diverse range of technologies for the directed evolution of proteins, particularly methods for generating diversity in the gene library and approaches for screening and selecting for variants with desired properties. The relative strengths and limitations of these approaches are highlighted to guide readers to appropriate strategies.

    • Michael S. Packer
    • David R. Liu
    Reviews
    Nature Reviews Genetics
    Volume: 16, P: 379-394

  • To characterize the contributions of individual amino acids to the structure or function of a protein, researchers have adopted directed evolution approaches, which use iterated cycles of mutagenesis and selection or screening to search vast areas of sequence space for sets of mutations that provide insights into the protein of interest.

    • Courtney M Yuen
    • David R Liu
    Comments & Opinion
    Nature Methods
    Volume: 4, P: 995-997