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Showing 1–3 of 3 results
Advanced filters: Author: "David R. Spring" Clear advanced filters

  • Two approaches have emerged for creating libraries of compounds for use in biological screening assays for drug discovery — fragment-based ligand design and diversity-oriented synthesis. Advocates of each approach discuss their favoured strategy.

    • Philip J. Hajduk
    • Warren R. J. D. Galloway
    • David R. Spring
    News & Views
    Nature
    Volume: 470, P: 42-43

  • Nature oxidizes biosynthetic intermediates into structurally and functionally diverse peptides. An iron-catalysed C–H oxidation mimics this approach in the lab, enabling chemists to synthesize structural analogues with ease.

    • Sean Bartlett
    • David R. Spring
    News & Views
    Nature Chemistry
    Volume: 9, P: 9-10

  • Lipopolysaccharide (LPS) from Gram-negative bacteria is a potent activator of the innate immune response. Clare Bryant and colleagues discuss recent exciting data that have revealed the structural basis of the recognition of LPS by the Toll-like receptor 4–MD2 complex.

    • Clare E. Bryant
    • David R. Spring
    • Nicholas J. Gay
    Reviews
    Nature Reviews Microbiology
    Volume: 8, P: 8-14