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Showing 1–3 of 3 results
Advanced filters: Author: "David Bartel" Clear advanced filters

  • Hox clusters, which confer axial patterning on bilaterian embryos, also contain microRNAs. This analysis suggests that these microRNAs specifically target the Hox genes that lie to their 3′ side, thereby reinforcing the dominance of posterior Hox genes over anterior ones.

    • Soraya Yekta
    • Clifford J. Tabin
    • David P. Bartel
    Research
    Nature Reviews Genetics
    Volume: 9, P: 789-796

  • Numerous long non-coding RNAs (lncRNAs) have emerged as having important and mechanistically diverse roles in gene regulation. However, for most lncRNAs, evolution is rapid and functions remain uncharacterized. This Review describes how comparative genomics and transcriptomics can provide broad insights into the functional importance and evolutionary trajectories of lncRNAs across species, and offers guidance for cross-species studies of lncRNAs.

    • Igor Ulitsky
    Reviews
    Nature Reviews Genetics
    Volume: 17, P: 601-614