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Showing 1–3 of 3 results
Advanced filters: Author: "David Goltzman" Clear advanced filters

  • The extracellular calcium-sensing receptor (CaSR) is a G protein-coupled receptor that has a key role in Ca2+homeostasis via its role in the parathyroid glands and kidneys. New evidence has shown that CaSR also regulates skeletal homeostasis. In this Review, David Goltzman and Geoffrey Hendy discuss the role of CaSR in chondrocytes and development of the cartilagenous growth plate, in osteoblasts and osteoclasts, and effects of CaSR on skeletal development and bone turnover.

    • David Goltzman
    • Geoffrey N. Hendy
    Reviews
    Nature Reviews Endocrinology
    Volume: 11, P: 298-307

  • Genome-wide association studies have recently furthered the understanding of the genetics of osteoporosis. The authors here present the major findings from these studies, the pathways that have been highlighted in the progress of the disease and strategies for future diagnosis and therapy development.

    • J. Brent Richards
    • Hou-Feng Zheng
    • Tim D. Spector
    Reviews
    Nature Reviews Genetics
    Volume: 13, P: 576-588