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Showing 1–5 of 5 results
Advanced filters: Author: "Dean Sheppard" Clear advanced filters

  • IL-17 is associated with asthma, and THH17 cells are found in the airways of individuals with asthma. Dean Sheppard and his colleagues now report that IL-17A (but not IL-17F) directly enhances contractile responses in airway smooth muscle cells. Mice lacking TH17 cells in the lungs exhibit reduced airway hyper-responsiveness in response to allergen challenge.

    • Makoto Kudo
    • Andrew C Melton
    • Dean Sheppard
    Research
    Nature Medicine
    Volume: 18, P: 547-554

  • It is shown that mice deficient for β8 integrin develop colitis, and that β8 needs to be expressed by dendritic cells rather than T cells for colitis to develop. In addition, a decrease of T cells in the gut but not adjacent lymph nodes in diseased animals is shown. It is concluded that αVβ8-mediated integrin activation of dendritic cells is essential for prevention of colitis-inducing immune dysfunction.

    • Mark A. Travis
    • Boris Reizis
    • Dean Sheppard
    Research
    Nature
    Volume: 449, P: 361-365

  • Collagen production by lung cells is critical to maintain organ architecture but can also drive pathological scarring. Here the authors perform single cell RNA sequencing of collagen-producing lung cells identifying a subset of pathologic fibroblasts characterized by Cthrc1 expression which are concentrated within fibroblastic foci in fibrotic lungs and show a pro-fibrotic phenotype.

    • Tatsuya Tsukui
    • Kai-Hui Sun
    • Dean Sheppard
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • Allergens stimulate lymphocytes to become factories for secreted proteins that cause organ dysfunction in allergic diseases. Allergens are now shown to target dendritic cells, the cells responsible for processing and presenting antigens to T cells (pages 565–573).

    • Dean Sheppard
    News & Views
    Nature Medicine
    Volume: 14, P: 487-488