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Advanced filters: Author: "Demin Wang" Clear advanced filters

  • IL-7R activation drives early B cell development, but the signalling is unclear. Here the authors show PLCγ is involved in IL-7R-induced mTOR activation via a DAG/PKC-dependent pathway, and that double deficiency of the two PLCγ isoforms arrests B cell development at the pre-pro-B stage in mice.

    • Mei Yu
    • Yuhong Chen
    • Demin Wang
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-18