Viruses such as HIV-1 must deliver their content into host T-cell nuclei to replicate. Here, Santos et al. show that endocytosed HIV-1 promotes nuclear envelope invagination mediated by VAP-A, ORP3, and Rab7 host protein complex that allow HIV-1 to access T-cell nuclei.
- Mark F. Santos
- Germana Rappa
- Aurelio Lorico