The calcium-sensing receptor (CaSR) can detect small changes in serum calcium levels and feeds back to modulate parathyroid hormone secretion to elicit appropriate biological responses in different tissues. In this Review, Daniela Riccardi and Giovanna Valenti describe the localization of the CaSR within the nephron and outline its differential functions in different nephron segments. They outline how modulation of the CaSR by pharmacologic approaches could be used in the therapeutic management of disorders such as hyperparathyroidism or hypercalciuric disorders.
- Daniela Riccardi
- Giovanna Valenti
