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Showing 1–5 of 5 results
Advanced filters: Author: "Dennis McGonagle" Clear advanced filters

  • In the past few years, excitement has grown over the potential use of mesenchymal stem cells (MSCs) for cartilage repair, although the rarity of these cells has hampered progress. In this Review, the authors examine the potential of joint-resident MSCs as a new avenue for repair in osteoarthritis.

    • Dennis McGonagle
    • Thomas G. Baboolal
    • Elena Jones
    Reviews
    Nature Reviews Rheumatology
    Volume: 13, P: 719-730

  • MRI has emerged as an important tool for the assessment of rheumatoid arthritis, and in research has had a clear impact on how the disease process is understood. In this Perspectives article, the authors consider the role of MRI in the evaluation of rheumatoid arthritis, including pathogenesis, diagnosis and outcomes of therapy, and examine the issues that surround the use of MRI in clinical and research settings.

    • Dennis McGonagle
    • Zoe R. Ash
    • Aleksandra Radjenovic
    Reviews
    Nature Reviews Rheumatology
    Volume: 7, P: 185-189

  • With advances in stem cell techniques for the bioengineering and regeneration of musculoskeletal tissues comes added complexity in our understanding of stem cell biology. How will the recent discovery of a novel stem cell subset, termed osteochondroreticular stem cells, contribute to progression in the field?

    • Dennis McGonagle
    • Elena A. Jones
    News & Views
    Nature Reviews Rheumatology
    Volume: 11, P: 200-201

  • This article provides an overview of the pathophysiology of enthesitis, from induction and inflammation to tissue proliferation and bone formation. Building on these pathophysiological concepts, the clinical presentation, assessment and treatment of enthesitis are also discussed.

    • Georg Schett
    • Rik J. Lories
    • Dennis McGonagle
    Reviews
    Nature Reviews Rheumatology
    Volume: 13, P: 731-741

  • This article presents the concept that Behçet disease and several spondyloarthropathies might have a common immunopathogenetic basis. The authors propose that barrier dysfunction in environmentally exposed organs, and aberrant innate immune reactions at sites of mechanical stress, trigger secondary adaptive immune CD8+T-cell responses characterized by prominent neutrophilic inflammation. The differential immunopathology of these 'MHC-I-opathies' could reflect antigenic differences in target tissues.

    • Dennis McGonagle
    • Sibel Zehra Aydin
    • Haner Direskeneli
    Reviews
    Nature Reviews Rheumatology
    Volume: 11, P: 731-740