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Showing 1–7 of 7 results
Advanced filters: Author: "Derek Toomre" Clear advanced filters

  • Molecular tethers physically bridge transport vesicles to their target membranes as a prerequisite step for fusion. Here the authors control vesicle tethering using optogenetic approaches to study the interplay between vesicle tethering and fusion.

    • Seong J. An
    • Felix Rivera-Molina
    • Derek Toomre
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • A central problem in the COVID-19 pandemic is that there is not enough testing to prevent infectious spread of SARS-CoV-2, causing surges and lockdowns with human and economic toll. Here, the authors evaluate an alternative strategy based on the monitoring of olfactory dysfunction with a mathematical model.

    • Daniel B. Larremore
    • Derek Toomre
    • Roy Parker
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9

  • HIDE probes were developed for long time-lapse imaging of endolysosomes and their dynamics at super-resolution. These probes enabled analyses of endosome motility in primary fibroblasts from patients with Niemann–Pick C with distinct mutations in NPC1.

    • Aarushi Gupta
    • Felix Rivera-Molina
    • Alanna Schepartz
    Research
    Nature Chemical Biology
    Volume: 16, P: 408-414

  • Integrins are cell-surface adhesion receptors that are modulated by endo-exocytic trafficking, but existing tools to study this process can interfere with function. Here the authors develop β1 integrins carrying traceable tags in the extracellular domain; a pH-sensitive pHlourin tag or a HaloTag to facilitate dye attachment.

    • Clotilde Huet-Calderwood
    • Felix Rivera-Molina
    • David A. Calderwood
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • High density environmentally sensitive (HIDE) probes allow for long time-lapse super-resolution imaging of live cells. Here the authors develop a second HIDE probe with a bio-orthogonal labelling strategy to enable two-color nanoscopy of two organelles over extended periods.

    • Ling Chu
    • Jonathan Tyson
    • Derek K. Toomre
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8