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Showing 1–3 of 3 results
Advanced filters: Author: "Didier Y. R. Stainier" Clear advanced filters

  • The coordinated control of endothelial cell behaviour is critical for blood vessel morphogenesis. Recent data reveal elaborate mechanisms that fine-tune key signalling pathways (such as the vascular endothelial growth factor and Notch pathways) to control endothelial cell behaviour during blood vessel sprouting (angiogenesis).

    • Shane P. Herbert
    • Didier Y. R. Stainier
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 551-564

  • Blood stem cells derive at least in part from an embryonic vessel called the dorsal aorta. It emerges that a flanking tissue called the somite contributes cells and signals to this process. See Letters p.314 & p.319

    • Suphansa Sawamiphak
    • Didier Y. R. Stainier
    News & Views
    Nature
    Volume: 512, P: 257-258

  • Loss-of-function (LOF) approaches are powerful experimental tools for characterizing gene functions. However, emerging discrepancies when genes are investigated using different tools or organisms has triggered debate about how such LOF results should be biologically interpreted. In this Review, experts from varied fields discuss how understanding the underlying features of each LOF approach can provide explanations for different experimental outcomes and can guide their optimal and reliable application.

    • Benjamin E. Housden
    • Matthias Muhar
    • Norbert Perrimon
    Reviews
    Nature Reviews Genetics
    Volume: 18, P: 24-40