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Showing 1–11 of 11 results
Advanced filters: Author: "Dietmar Zehn" Clear advanced filters

  • Starting on 19 September 2022, the very first ImmunOctoberfest conference took place in Raitenhaslach, Germany, bringing together scientists from all over the world to discuss ‘bridging innovation and translation in T cell immunotherapy’.

    • Anna M. Schulz
    • Caitlin C. Zebley
    • Dietmar Zehn
    News & Views
    Nature Immunology
    Volume: 24, P: 213-215

  • In this Viewpoint article, Nature Reviews Immunology invites 18 experts to discuss the nature of T cell exhaustion. How should T cell exhaustion be defined and what are the developmental relationships between exhausted T cell subsets? The contributors share their thoughts on key recent developments in the field.

    • Christian U. Blank
    • W. Nicholas Haining
    • Dietmar Zehn
    Reviews
    Nature Reviews Immunology
    Volume: 19, P: 665-674

  • Here the authors show that dihydroorotate dehydrogenase in the de novo pyrimidine synthesis pathway functions as a cell fate checkpoint that can be targeted to specifically diminish the number and function of effector T cells without affecting the memory T cell pool and response to infection.

    • Stefanie Scherer
    • Susanne G. Oberle
    • Dietmar Zehn
    Research
    Nature Immunology
    Volume: 24, P: 501-515

  • Chronic viral infections and malignant tumours are associated with the development of T cells that have an 'exhausted' phenotype and that are thought to be severely functionally impaired. In this Opinion article, the authors propose that the exhausted phenotype is actually a functional adaptation to cause minimal tissue damage while still mediating a critical level of pathogen control.

    • Daniel E. Speiser
    • Daniel T. Utzschneider
    • Dietmar Zehn
    Reviews
    Nature Reviews Immunology
    Volume: 14, P: 768-774

  • For decades, beta-blockers have been used widely to treat cardiovascular diseases. Surprisingly, new data show how these inhibitors can also improve immunotherapy against tumors and chronic infections.

    • Jacqueline Berner
    • Dietmar Zehn
    News & Views
    Nature Immunology
    Volume: 24, P: 1792-1793

  • Single-cell RNA-seq offers the opportunity to improve efficacy of T-cell based immunotherapy. Here the authors develop a plate-based method for cytotoxic T cell profiling. It captures a higher number of transcripts and detects gene with increased dynamic range in comparison to droplet-based methods.

    • Kristiyan Kanev
    • Patrick Roelli
    • Dietmar Zehn
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • In contrast with the classical dogma that the pathways generating either memory or ‘exhausted’ T cells are strictly segregated, data now identify a clonally distinct hybrid memory T cell subpopulation with an exhausted phenotype.

    • Talyn Chu
    • Jacqueline Berner
    • Dietmar Zehn
    News & Views
    Nature Immunology
    Volume: 21, P: 1484-1485