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Showing 1–3 of 3 results
Advanced filters: Author: "Dihua Yu" Clear advanced filters

  • Activation of hypoxia-inducible factor, a molecule central to oxygen sensing, can promote the survival and growth of tumor cells. New experiments dissect a pathway behind this effect—upregulation of the epidermal growth factor receptor (pages 319–324).

    • Mien-Chie Hung
    • Gordon B Mills
    • Dihua Yu
    News & Views
    Nature Medicine
    Volume: 15, P: 246-247

  • Despite the impressive results seen in phase II trials of trastuzumab, many tumors that overexpress HER2 show resistance to the drug. Understanding the molecular mechanisms underlying primary or treatment-induced trastuzumab resistance is critical to improving the survival of patients with metastatic breast cancer with aggressive HER2 overexpressing tumors. This review discusses the novel therapeutic strategies that target the aberrant molecular pathways, and explains how these strategies could greatly improve the duration of response to trastuzumab.

    • Rita Nahta
    • Dihua Yu
    • Francisco J Esteva
    Reviews
    Nature Clinical Practice Oncology
    Volume: 3, P: 269-280

  • Trastuzumab and lapatinib improve survival in patients with HER2-positive breast cancer and there is great interest in developing diagnostic tests that predict which patients are more likely to benefit from specific HER2-directed therapies. This article discusses the predictive role ofHER2mRNA, predictive markers for response to therapy and the mechanisms for overcoming resistance in metastatic disease.

    • Francisco J. Esteva
    • Dihua Yu
    • Gabriel N. Hortobagyi
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 7, P: 98-107