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Showing 1–4 of 4 results
Advanced filters: Author: "Dimitri P. Mikhailidis" Clear advanced filters

  • The new ACC/AHA guidelines on treatment of blood cholesterol focus on intensity of statin therapy rather than target levels of lipids. Early studies show substantial reductions in LDL-cholesterol level with antibodies against PCSK9. MicroRNA silencing and gene-repair techniques to treat dyslipidaemia are promising strategies under development.

    • Dimitri P. Mikhailidis
    • Vasilios G. Athyros
    News & Views
    Nature Reviews Cardiology
    Volume: 11, P: 72-74

  • Two recent studies suggest that periprocedural statin administration can prevent contrast-induced acute kidney injury in cardiac patients undergoing percutaneous coronary intervention and in renal patients undergoing angiography, with or without intervention. These studies support the routine administration of potent statins before contrast media infusion in these vulnerable patients.

    • Dimitri P. Mikhailidis
    • Vasilios G. Athyros
    News & Views
    Nature Reviews Nephrology
    Volume: 10, P: 8-9

  • A new report examines trends in caloric and fat intake—known modifiers of cardiovascular risk—among statin users and non-users. As statins are the most effective hypolipidaemic agents currently used to prevent cardiovascular disease, it is important to understand how statin treatment affects dietary attitude.

    • Vasilios G. Athyros
    • Dimitri P. Mikhailidis
    News & Views
    Nature Reviews Endocrinology
    Volume: 10, P: 450-451

  • Toll-like receptors (TLRs) have a key role in the regulation of innate immunity by mediating signal transduction pathways that modulate the expression of proinflammatory cytokines and chemokines. This Review discusses the potential role of TLRs in the pathogenesis of renal conditions such as acute kidney injury, acute glomerulonephritis, and renal transplant rejection. The authors also describe studies that have used pharmacological inhibition of TLR signaling to modify the response to proinflammatory stimuli.

    • Anna Gluba
    • Maciej Banach
    • Jacek Rysz
    Reviews
    Nature Reviews Nephrology
    Volume: 6, P: 224-235