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Showing 1–2 of 2 results
Advanced filters: Author: "Dominic P. Kwiatkowski" Clear advanced filters

  • The impact of various infectious agents on human survival and reproduction over thousands of years has exerted selective pressure on numerous regions of the human genome. This Review describes how such signatures of selection can be detected and integrated with data from complementary approaches, such as genome-wide association studies, to provide biological insights into host–pathogen interactions.

    • Elinor K. Karlsson
    • Dominic P. Kwiatkowski
    • Pardis C. Sabeti
    Reviews
    Nature Reviews Genetics
    Volume: 15, P: 379-393

  • Genome-wide association studies are not widespread in Africa, partly because of the challenges of dealing with population structure and high genomic diversity. New approaches in statistical imputation and whole-genome sequencing are now set to exploit these features for fine mapping causal variants.

    • Yik-Ying Teo
    • Kerrin S. Small
    • Dominic P. Kwiatkowski
    Reviews
    Nature Reviews Genetics
    Volume: 11, P: 149-160