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Showing 1–5 of 5 results
Advanced filters: Author: "Don W. Cleveland" Clear advanced filters

  • Guide RNA-mediated CRISPR–Cas nucleases are a powerful technology for the engineering of mammalian genomes. CRISPR–Cas9-dependent editing of mutated genes that cause Huntington disease and fragile X syndrome was recently achieved in cell-based models, heralding the first step towards developing this technology into viable therapeutics for neurological diseases.

    • Moira A. McMahon
    • Don W. Cleveland
    News & Views
    Nature Reviews Neurology
    Volume: 13, P: 7-9

  • A new study shows that loss of the lariat debranching enzyme Dbr1 suppresses TDP-43 toxicity. The accumulated intronic lariat RNAs, which are normally degraded after splicing, likely act as decoys to sequester TDP-43 away from binding to and disrupting functions of other RNAs.

    • Shuying Sun
    • Don W Cleveland
    News & Views
    Nature Genetics
    Volume: 44, P: 1289-1291

  • That mutations in the SOD1 enzyme underlie inherited forms of a motor neuron disease known as ALS is clear. But the question of what the consequences of such mutations are seems to have more than one answer.

    • Magdalini Polymenidou
    • Don W. Cleveland
    News & Views
    Nature
    Volume: 454, P: 284-285

  • Aggregates and mutations of the proteins ataxin-2 and TDP-43 have been implicated in distinct neurodegenerative disorders. An interplay between these proteins is now reported for amyotrophic lateral sclerosis.

    • Clotilde Lagier-Tourenne
    • Don W. Cleveland
    News & Views
    Nature
    Volume: 466, P: 1052-1053

  • Microtubule nucleation is regulated by the γ-tubulin small complex (γTuSC) and the γ-tubulin ring complex (γTuRC). Recent structural work, including the crystallographic analysis of γ-tubulin complex protein 4 (GCP4), provides new insights into the mechanism of γTuRC-based microtubule nucleation, confirming the hypothesis that the γTuRC functions as a microtubule template.

    • Justin M. Kollman
    • Andreas Merdes
    • David A. Agard
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 709-721