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Showing 1–4 of 4 results
Advanced filters: Author: "E John Wherry" Clear advanced filters

  • Exhausted T cells display a phenotype characterized by progressive loss of function, and they can develop following exposure to persistent antigen and/or inflammatory signals during chronic viral infections or cancer. The authors describe the molecular mechanisms of T cell exhaustion and how the exhausted phenotype is different from other dysfunctional states of T cells.

    • E. John Wherry
    • Makoto Kurachi
    Reviews
    Nature Reviews Immunology
    Volume: 15, P: 486-499

  • A new study demonstrates involvement of the inhibitory receptor CTLA-4 in T cell exhaustion during infection with human immunodeficiency virus, adding complexity and diversity to the inhibitory pathways regulating T cell responses during chronic viral infections in humans.

    • Alison Crawford
    • E John Wherry
    News & Views
    Nature Immunology
    Volume: 8, P: 1201-1203

  • An algorithm developed with a systems-biology approach reconstructs some of the key regulatory events known to drive the development of cells of the mouse immune system and makes many other novel predictions for testing.

    • Christelle Harly
    • E John Wherry
    • Avinash Bhandoola
    News & Views
    Nature Immunology
    Volume: 14, P: 529-531