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Showing 1–3 of 3 results
Advanced filters: Author: "E. Roberts" Clear advanced filters

  • Small molecules that safely antagonize amyloidogenesis are desperately needed for many devastating disorders that plague humankind, including Alzheimer's and Parkinson's diseases. New work brings important mechanistic insights into how one promising candidate, (−)-epigallocatechin-3-gallate (EGCG), diverts amyloid-β and α-synuclein down innocuous folding trajectories at the expense of the deleterious states populated during amyloidogenesis.

    • Blake E Roberts
    • James Shorter
    News & Views
    Nature Structural & Molecular Biology
    Volume: 15, P: 544-546

  • Tinnitus, prevalent in up to 15% of the world population, is typically linked to noise-associated hearing loss, but the relationship between noise exposure and tinnitus is not straightforward: not all humans or model animals develop tinnitus after noise-associated cochlear damage, and the mechanisms involved in tinnitus involve central auditory system and nonauditory brain areas. This Review provides an overview of current understanding of neural mechanisms of tinnitus, which is essential for developing effective treatments for this disorder.

    • Susan E. Shore
    • Larry E. Roberts
    • Berthold Langguth
    Reviews
    Nature Reviews Neurology
    Volume: 12, P: 150-160