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Showing 1–4 of 4 results
Advanced filters: Author: "Edward A. Miao" Clear advanced filters

  • Inflammasomes are protein complexes that fight infection by driving inflammation or cell death. It now seems that the protein NEK7 provides a ‘licence’ for the formation of inflammasomes containing the protein NLRP3.

    • Kengo Nozaki
    • Edward A. Miao
    News & Views
    Nature
    Volume: 570, P: 316-317

  • Feedback inhibition by interferon-γ blocks the NLRP3 inflammasome by triggering inducible nitric oxide synthase (iNOS), and the resulting nitric oxide (NO) thio-nitrosylates NLRP3, shutting it down. This prevents excessive immunopathology during chronic infection with Mycobacterium tuberculosis.

    • Manira Rayamajhi
    • Edward A Miao
    News & Views
    Nature Immunology
    Volume: 14, P: 12-14

  • Vesicular stomatitis virus, a single-stranded RNA virus, triggers activation of the serine-threonine kinases RIP1 and RIP3, which damages mitochondria by activating the GTPase DRP1. This results in excessive production of reactive oxygen species and subsequent activation of the NLRP3 inflammasome.

    • Manira Rayamajhi
    • Edward A Miao
    News & Views
    Nature Immunology
    Volume: 15, P: 1100-1102

  • This Review describes how different modes of cell death protect against bacterial and viral infections, and the complex signalling crosstalk between the different pathways during an infection.

    • Ine Jorgensen
    • Manira Rayamajhi
    • Edward A. Miao
    Reviews
    Nature Reviews Immunology
    Volume: 17, P: 151-164