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Showing 1–2 of 2 results
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  • Cells with defects in the autophagic pathway are sensitized to apoptosis in response to metabolic stress, but, paradoxically, autophagy defects are associated with increased tumorigenesis. How can this paradox be resolved?

    • Robin Mathew
    • Vassiliki Karantza-Wadsworth
    • Eileen White
    Reviews
    Nature Reviews Cancer
    Volume: 7, P: 961-967

  • Autophagy can have two functions in cancer: it can be tumour suppressive or tumour promoting. Therefore, defining the context-specific role for autophagy in cancer and the mechanisms involved is important for the use of autophagy-based therapeutics.

    • Eileen White
    Reviews
    Nature Reviews Cancer
    Volume: 12, P: 401-410