The perioperative timeframe is pivotal in determining long-term cancer outcomes. This Review covers the various aspects of surgery which could facilitate the metastatic process. Through understanding these processes and reviewing empirical evidence, the authors provide suggestions for potential new perioperative interventions aimed at attenuating deleterious processes and improving treatment outcomes. The measures described in this Review could transform the perioperative timeframe from a prominent facilitator of metastatic progression, to a window of opportunity for arresting and/or eliminating residual disease.
- Maya Horowitz
- Elad Neeman
- Shamgar Ben-Eliyahu
