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Showing 1–7 of 7 results
Advanced filters: Author: "Eldad Tzahor" Clear advanced filters

  • The extracellular matrix protein agrin promotes cardiac regeneration in adult mice after myocardial infarction; it modulates cardiac differentiation and proliferation by interacting with the dystrophin–glycoprotein complex, Yap and ERK-mediated signalling.

    • Elad Bassat
    • Yara Eid Mutlak
    • Eldad Tzahor
    Research
    Nature
    Volume: 547, P: 179-184

  • Shakked et al. highlight the importance of cardiomyocytes’ redifferentiation after dedifferentiation and proliferation in cardiac repair and show that redifferentiation depends on negative feedback signaling and LATS1/2 Hippo pathway activity. Cardiomyocyte redifferentiation not only promotes the restoration of cardiac function but also protects against future insult.

    • Avraham Shakked
    • Zachary Petrover
    • Eldad Tzahor
    Research
    Nature Cardiovascular Research
    Volume: 2, P: 383-398

  • Secreted Frizzled-related proteins (sFRPs) are signalling molecules well-known as antagonists of the Wnt pathway, but recent studies indicate that they may have additional functions unrelated to Wnt. A new study demonstrates that mammalian sFRP2 can act as an enhancer of collagen processing in vitro and in vivo, augmenting myocardial injury-driven fibrosis. These findings underscore the biological versatility of sFRP family members.

    • Elisha Nathan
    • Eldad Tzahor
    News & Views
    Nature Cell Biology
    Volume: 11, P: 13

  • Aharonov et al. use in vivo genetic approaches to show that ErBB2-mediated YAP activation initiates epithelial–mesenchymal transition-like processes and dedifferentiation of cardiomyocytes to drive heart regeneration.

    • Alla Aharonov
    • Avraham Shakked
    • Eldad Tzahor
    Research
    Nature Cell Biology
    Volume: 22, P: 1346-1356

  • How do we measure the impact of scientific research? A new study discusses the current publication culture, diverse animal models that are commonly used in cardiovascular studies, the comparison between basic and clinical research paths, and the role of authors and reviewers in bringing these two paths together.

    • Eldad Tzahor
    • Karina Yaniv
    Comments & Opinion
    Nature Cardiovascular Research
    Volume: 1, P: 2-3